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Categories: Transmembrane receptors Articles to be merged from September 2009 All articles to be merged Wikipedia articles needing copy edit from March 2008 All articles needing copy edit |
Summary Of: PD-1PD-1 is a member of the extended CD28... which suggests that PD-1 negatively regulates TCR signals... 2 phosphatases to the cytoplasmic tail of PD-1 upon ligand binding... PD-1 is expressed on the surface of activated T cells... PD-1 more broadly negatively regulates immune responses... Many studies indicate that PD-1 and its ligands negatively regulate immune responses... PD-1 knockout mice develop lupus... these data suggest that PD-1 negatively regulates T cell responses... the closely related molecule PD-1 has been independently explored as a target for... PD-1 knockout 2C T cells have heightened cytolytic capacity and IL... suggesting that PD-1 negatively regulates anti... tumor activity through engagement of PD-1 on effector T cells... highlighting the relevance of exploring the PD-1 pathway as a target for immunotherapy...Encyclodia Page On: PD-1
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