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Summary Of: Taxol

head reviewed the data and finally recommended that taxol be moved on to the next stage in the discovery process... two NCI researchers published a report showing that taxol was mildly effective in leukaemic mice... taxol was shown to be effective in... Meanwhile taxol began to be well known in the cell biology... that showed that taxol had a previously unknown mechanism of action involving the stabilization of... then it was recognized that the demand for taxol might be substantial and that more than 60... Product Branch calculated that the synthesis of enough taxol to treat all the ovarian cancer and melanoma cases in the US would require the... argued that the name taxol had been used for more than two decades and in more than 600 scientific articles... scientist doing the isolation who named the compound taxol and it was not referred to in any other way for more than twenty years... that taxol was successfully extracted on a clinically useful scale from these sources... In 1993 it was discovered that taxol was coincidentally produced in a newly described... Taxol and Taxane Production by Taxomyces... opening the possibility of taxol production by culturing one of these fungal species... Taxol is approved in the UK for ovarian cancer... Much of the clinical toxicity of Taxol is associated with the solvent... activated Taxol prodrugs are undergoing continued testing... able to treat more types of cancer than Taxol has been able to treat... activated Taxol prodrugs are designed for accurate targeting... Activated Taxol prodrugs research is progressing... Phase II study of taxol in advanced epithelial malignancies... Development of a Green Synthesis for Taxol Manufacture via Plant Cell Fermentation and Extraction... Taxol Crystals Can Masquerade as Stabilized Microtubules... paclitaxel demonstrates superior efficacy vs taxol in metastatic breast cancer...

Encyclodia Page On: Taxol

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| IUPAC | CAS number | ATC code | L01 | L01 | PubChem | DrugBank | ChemSpider | Formula | C | H | N | O | Mol. mass | g | mol | Bioavailability | Protein binding | Metabolism | Hepatic | CYP2C8 | CYP3A4 | Half life | Excretion | Pregnancy cat. | US | Legal status | Routes | iv | mitotic inhibitor | cancer | chemotherapy | National Cancer Institute | Research Triangle Institute | Mansukh C. Wani | yew | Taxus brevifolia | Bristol-Myers Squibb | Cremophor EL | ethanol | albumin | Abraxane | lung | ovarian | breast cancer | Kaposi's sarcoma | restenosis | microtubules | docetaxel | taxanes | total synthesis | Robert A. Holton | | | National Cancer Institute | natural product | USDA | August 21 | 1962 | Taxus brevifolia | Packwood, Washington | 22 May | 1964 | Research Triangle Park | North Carolina | American Chemical Society | xenograft | Albert Einstein College of Medicine | microtubules | INDA | Phase I | Phase II | Cooperative Research and Development Agreement | Bristol-Myers Squibb | General Accounting Office | USDA | Department of the Interior | monopoly | new drug application | Nature | US$ | | | | | Robert A. Holton | total synthesis of the molecule | petrochemical | CNRS | 10-deacetylbaccatin | Florida State University | Bristol-Myers Squibb | fungus | Gary Strobel | endophytic | docetaxel | microtubule | colchicine | cytoskeleton | β subunit of tubulin | mitosis | chromosomes | apoptosis | Bcl-2 | cancer cells | Kaposi's sarcoma | NICE | docetaxel | Cremophor | Abraxane | albumin | Food and Drug Administration | Taxol | Abraxane | restenosis | stents | coronary artery | drug eluting coated stents | Boston Scientific | excipient | Cremophor EL | castor oil | Dexamethasone | microtubule | In vitro | motor proteins | in vivo | fruit flies | | | doi | doi | ISBN 052156123X | doi | The Progressive | March 9 | 2007 | doi | Journal of Biological Chemistry | doi | Food and Drug Administration | January 7 | 2005 | March 9 | 2007 | MEDLINE | April 1 | 2003 | March 9 | 2007 | University of Bristol | Florida State University | The New York Times | v | d | chemotherapeutic agents | antineoplastic agents | L01 | SPs | MIs | M phase | microtubule | Vinca alkaloids | Vinblastine | Vincristine | Vinflunine | Vindesine | Vinorelbine | Taxanes | Docetaxel | Larotaxel | Ortataxel | Tesetaxel | Epothilones | Ixabepilone | DNA replication | antimetabolites | S phase | Folic acid | Aminopterin | Methotrexate | Pemetrexed | Raltitrexed | Purine | Cladribine | Clofarabine | Fludarabine | Mercaptopurine | Pentostatin | Thioguanine | Pyrimidine | Carmofur | Cytarabine | Decitabine | Fluorouracil | Capecitabine | Tegafur | Floxuridine | Gemcitabine | Enocitabine | Sapacitabine | Deoxyribonucleotide | Hydroxyurea | Topoisomerase inhibitors | S phase | Camptotheca | Camptothecin | Topotecan | Irinotecan | Rubitecan | Belotecan | Podophyllum | Etoposide | Teniposide | Anthracenediones | Mitoxantrone | Pixantrone | Anthracyclines | Aclarubicin | Daunorubicin | Doxorubicin | Epirubicin | Idarubicin | Amrubicin | Pirarubicin | Valrubicin | Zorubicin | Crosslinking of DNA | CCNS | Alkylating | Nitrogen mustards | Chlorambucil | Chlormethine | Cyclophosphamide | Ifosfamide | Melphalan | Bendamustine | Trofosfamide | Uramustine | Nitrosoureas | Carmustine | Fotemustine | Lomustine | Nimustine | Prednimustine | Ranimustine | Semustine | Streptozocin | Alkyl sulfonates | Busulfan | Mannosulfan | Treosulfan | Hydrazines | Procarbazine | Triazenes | Dacarbazine | Temozolomide | Aziridines | Carboquone | ThioTEPA | Triaziquone | Triethylenemelamine | Altretamine | Estramustine | Irofulven | Mitobronitol | Platinum | Carboplatin | Cisplatin | Nedaplatin | Oxaliplatin | Triplatin tetranitrate | Satraplatin | Streptomyces | Actinomycin | Bleomycin | Mitomycin | Plicamycin | Photosensitizers | PDT | Aminolevulinic acid | Methyl aminolevulinate | Efaproxiral | Porphyrin derivatives | Porfimer sodium | Talaporfin | Temoporfin | Verteporfin | Enzyme inhibitors | FI | Tipifarnib | CDK | inhibitors | Alvocidib | Seliciclib | PrI | Bortezomib | PhI | Anagrelide | IMPDI | Tiazofurine | LI | Masoprocol | Receptor antagonists | ERA | Atrasentan | retinoid X receptor | Bexarotene | sex steroid | Testolactone | Amsacrine | Trabectedin | retinoids | Alitretinoin | Tretinoin | Arsenic trioxide | asparagine depleter | Asparaginase | Pegaspargase | Celecoxib | Demecolcine | Elesclomol | Elsamitrucin | Etoglucid | Lonidamine | Lucanthone | Mitoguazone | Mitotane | Oblimersen | Vorinostat | Categories | Chemotherapeutic agents | Bristol-Myers Squibb | Alkaloids | Terpenes and terpenoids |
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